Drug allergy in older adults presents unique challenges due to age-related changes, multiple medical conditions, and the use of numerous medications. These factors increase the risk of both allergic reactions and diagnostic confusion.

As people age, immune responses may change, sometimes making allergic reactions less obvious or atypical. Symptoms such as confusion, weakness, or falls may be the first indicators rather than classic skin or respiratory signs. This can delay diagnosis and appropriate treatment.

Polypharmacy is a major concern in older adults. Taking multiple medications increases the likelihood of drug interactions and allergic reactions. It also complicates identifying which medication is responsible for symptoms.

Chronic conditions such as kidney or liver disease can alter how drugs are processed, potentially intensifying reactions. Older adults may also have difficulty recalling previous drug reactions, making accurate medical history collection challenging.

Management focuses on careful medication review, clear documentation of confirmed allergies, and cautious prescribing. Simplifying medication regimens when possible reduces risk. Regular follow-ups help detect reactions early.

Education for patients and caregivers is essential. Understanding warning signs and knowing when to seek medical attention can prevent serious complications.

With attentive care and communication, drug allergies in older adults can be managed effectively, improving safety and quality of life.